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Item Details
Title: DIAGNOSTIC AND THERAPEUTIC ANTIBODIES
By: Andrew George, Catherine E. Urch
Format: Hardback

List price: £129.99


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ISBN 10: 0896037983
ISBN 13: 9780896037984
Publisher: HUMANA PRESS INC.
Pub. date: 1 August, 2000
Edition: 2000 ed.
Pages: 477
Description: Reviews the theoretical and practical aspects of applying antibodies in both the laboratory and clinic. This book introduces the basic science of the antibody molecule, including recombinant engineering. It presents several novel in vivo applications of therapeutic antibodies to illustrate their special value in varied clinical settings.
Synopsis: Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the "magic bullet" that would allow the specific destruction of neoplastic cells. H- ever, many years' effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science as well as in other things, tends to be cyclical. Antibody-based therapy is once again attracting scientists and clinicians. There are several reasons for the renewed optimism; certainly the expe- ence of the last two decades has provided a wealth of information about problems associated with antibody therapy, and possible solutions to these problems. Recombinant antibody engineering has rejuvenated the field, allowing both the modification of antibodies to improve their in vivo pr- erties and the isolation of novel antibody molecules by such techniques as phage display.The results of recent clinical trials have demonstrated unequivocally the benefit of antibody therapy in a number of settings, and, finally, more careful consideration has been taken of the types of disease best treated using this approach.
Illustrations: biography
Publication: US
Imprint: Humana Press Inc.
Returns: Returnable
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