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Item Details
| Title:
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STRUCTURE-BASED DESIGN OF DRUGS AND OTHER BIOACTIVE MOLECULES
TOOLS AND STRATEGIES |
| By: |
Arun K. Ghosh, Sandra Gemma |
| Format: |
Hardback |
| List price:
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£100.00 |
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We believe that this item is permanently unavailable, and so we cannot source
it.
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| ISBN 10: |
3527333657 |
| ISBN 13: |
9783527333653 |
| Publisher: |
WILEY-VCH VERLAG GMBH |
| Pub. date: |
18 June, 2014 |
| Pages: |
474 |
| Description: |
The modern guide to designing drugs and other bioactive molecules by a combination of structural biology, synthetic chemistry and computational methods. Clearly written and with many illustrative case studies from "designed" molecules that have become important medicines. |
| Synopsis: |
In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design. As a result, this practical book demonstrates how to develop a high-affinity ligand with drug-like properties for any given drug target for which a high-resolution structure exists. The authors, both of whom have successfully designed drug-like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in structure-based drug design with the novice in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. |
| Illustrations: |
illustrations (black and white, and colour) |
| Publication: |
Germany |
| Imprint: |
Wiley-VCH Verlag GmbH |
| Returns: |
Returnable |
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