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Item Details
| Title:
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BIOPHYSICS OF COMPUTATION
INFORMATION PROCESSING IN SINGLE NEURONS |
| By: |
Christof Koch |
| Format: |
Hardback |
| List price:
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£52.00 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
0195104919 |
| ISBN 13: |
9780195104912 |
| Publisher: |
OXFORD UNIVERSITY PRESS INC |
| Pub. date: |
1 November, 1998 |
| Series: |
Computational Neuroscience No.1 |
| Pages: |
586 |
| Description: |
Addressing questions at the interface of biophysics and computational theory, this book explores how information is encoded in single neurons. It focuses centrally on the character of computation carried out by individual neurons using synapses, dendrites, and voltage-dependent ionic currents. |
| Synopsis: |
Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. This textbook rectifies the situation by focusing on the repertoire of computational operations available to individual nerve cells. The author suggests how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, and in the timing of individual spikes, or nerve impulses.Key topics include the linear cable operation, passive dendritic trees and dendritic spines, chemical and electrical synapses and how to treat them from a computational point of view, nonlinear interactions in passive and active dendritic trees, the Hodgkin-Huxley model of action potential generation and propagation, phase space analysis, linking stochastic ionic channels to membrane dependent currents, calcium and potassium currents and their role in information processing, the role of diffusion, buffering and binding of calcium and other messenger systems of information processing and storage, short- and long-term models of synaptic plasticity, simplified models of single cells, stochastic aspects of neuronal firing, the nature of neuronal code and unconventional models of computation involving molecules, puffs of gas, or neuropeptides. Each chapter ends with a recapitulation of the material presented, and the ultimate chapter presents a summary view of 'neuron-style' computation, ending with a list of strategic questions for research. |
| Illustrations: |
5 halftones, 226 line drawings, bibliography |
| Publication: |
US |
| Imprint: |
Oxford University Press Inc |
| Returns: |
Non-returnable |
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