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Item Details
| Title:
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TOP DRUGS: TOP SYNTHETIC ROUTES
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| By: |
John Saunders |
| Format: |
Paperback |
| List price:
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£27.99 |
| Our price: |
£24.49 |
| Discount: |
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| You save:
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£3.50 |
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| ISBN 10: |
0198501005 |
| ISBN 13: |
9780198501008 |
| Availability: |
Usually dispatched within 1-3 weeks.
 Delivery
rates
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| Stock: |
Currently 0 available |
| Publisher: |
OXFORD UNIVERSITY PRESS |
| Pub. date: |
18 May, 2000 |
| Series: |
Oxford Chemistry Primers 90 |
| Pages: |
96 |
| Description: |
This book will allow students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. Many of today's best selling drugs are first made in the chemical laboratory on a very small scale many years before they enter the market place. During the intervening period, organic chemists investigate alternative methods both to improve the overall yield of the process and to ensure that it operates safely on amanufacturing scale. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis. |
| Synopsis: |
Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis. |
| Illustrations: |
numerous line illustrations |
| Publication: |
UK |
| Imprint: |
Oxford University Press |
| Returns: |
Returnable |
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