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Item Details
Title: TYROSINE PHOSPHOPROTEIN PHOSPHATASES
By: Barry J. Goldstein
Format: Paperback

List price: £98.00


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ISBN 10: 0198502478
ISBN 13: 9780198502470
Publisher: OXFORD UNIVERSITY PRESS
Pub. date: 30 April, 1998
Edition: 2nd Revised edition
Series: Protein Profiles
Pages: 272
Description: Tyrosine phosphoprotein phosphatases are a family of enzymes found ubiquitously in cells, and are involved in a number of metabolic and signalling pathways. This volume explores their sequence, structure, and biochemical properties, providing a unique reference work for researchers. It also includes an extensive, categorized bibliography.
Synopsis: Tyrosine phosphoprotein phosphatases (PTPases) are found ubiquitously in cytosolic and particulate fractions of cells. They are unique in terms of their substrate sensitivity, neutral pH optimum, resistance to EDTA, and inhibition by low concentrations of zinc or vandanate. PTPases exert both positive and negative effects on a number of metabolic and signal transduction pathways. This volume explores the sequence, structure, and biochemical properties of PTPases, regulation of PTPase expression, substrate preferences and catalytic mechanisms, physiology, covalent modification, modification by chemical agents and proteolysis, and interactions with other proteins, peptides, and macromolecules. There is an extensive bibliography to assist the reader in further research.
Illustrations: 10 line figures
Publication: UK
Imprint: Oxford University Press
Returns: Returnable
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