EUKARYOTIC MRNA PROCESSING by Adrian R. Krainer (Editor) ( 9780199634170 )

Item Details

Title:

EUKARYOTIC MRNA PROCESSING

By:

Format:

Paperback

List price:	£98.00
We currently do not stock this item, please contact the publisher directly for further information.

ISBN 10:

0199634173

ISBN 13:

9780199634170

Publisher:

OXFORD UNIVERSITY PRESS

Pub. date:

7 August, 1997

Series:

Frontiers in Molecular Biology 17

Pages:

396

Description:

This volume reviews the principal steps in the maturation of protein-coding messenger RNA in the cell nucleus. These maturation reactions are essential for proper gene function and to regulate the expression of each gene in different kinds of cells or at different times during embryonic development. In each chapter, leading researchers have provided detailed, critical reviews of the history, experimental approaches, major advances, current ideas and models, as wellas future directions, for each of these active areas of research. The book will be of interest to students, teachers, and researchers interested in gene expression.

Synopsis:

This volume focuses on the major aspects of post-transcriptional mRNA processing in the nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper gene expression and can also serve as a control point for regulating the expression of many genes, for example during embryonic development or in different cell types.The different chapters review the assembly of newly synthesized nuclear mRNA transcripts into hnRNP particles and catalytically active spliceosomes; the structure and mechanism of action of small nuclear ribonucleoprotein particles and protein factors that catalyse pre-mRNA splicing in mammalian cells and in yeast; the regulation of gene expression and generation of protein isoform diversity by alternative splicing; the mechanisms of 3' end cleavage and polyadenylation; the architecture of the cell nucleus in relation to these processes and to the localization of the relevant substrates and factors; the diverse mechanisms of RNA processing by ribozymes and their potential relevance for nuclear mRNA processing; the mechanism of spliced-leader addition by trans-splicing in nematodes and trypanosomes; and the process of insertion/deletion mRNA editing in kinetoplasmid protozoa. In each chapter, leading researchers have provided detailed, critical reviews of the history, experimental approaches, major advances, current ideas and models, as well as future directions, for each of these active areas of research.

Illustrations:

line figures, tables

Publication:

Imprint:

Oxford University Press

Returns:

Returnable