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Item Details
| Title:
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GENOMIC IMPRINTING
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| By: |
Wolf Reik (Editor), Azim Surani (Editor) |
| Format: |
Paperback |
| List price:
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£98.00 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
0199636257 |
| ISBN 13: |
9780199636259 |
| Publisher: |
OXFORD UNIVERSITY PRESS |
| Pub. date: |
11 September, 1997 |
| Series: |
Frontiers in Molecular Biology 18 |
| Pages: |
268 |
| Description: |
Some genes have been shown to be marked in some way by parents for preferential treatment in the offspring. How well the gene functions can vary depending on which parent transmitted it. This phenomenon of genomic imprinting has been know since the late 1970s and is important in some inherited diseases, but it is only now that questions surrounding the mechanism of imprinting are being answered. This volume reviews the latest exciting developments, discusses some ofthe unanswered questions, and outlines directions for future research. |
| Synopsis: |
Genomic imprinting, the differential marking of genes inherited from paternal and maternal sources, has been recognized since the late 1970s and is known to be involved in several inherited diseases. However, it is only very recently that questions surrounding the mechanisms of genomic imprinting have begun to be answered. This volume reviews the latest exciting developments, with full citations of all of the key bibliography. It also discusses the major unanswered questions in this field and outlines directions for future research.Topics covered in Genomic Imprinting include: the role of DNA methylation in mammalian development; developmental regulation of imprinting by DNA methylation; imprinting at the mouse and human IGF2R loci; function and epigenetic modification of the imprinted H19 gene; the imprinted insulin-like growth factor 2 gene; consequences of genomic imprinting for fetal development; genomic imprinting in the mouse; systematic approaches for the identification of imprinted genes; genomic imprinting as a developmental process disturbed in cancer; imprinting in the PraderWilli/Angelman syndrome region on human chromosome 15; convergent themes in X chromosome inactivation and autosomal imprinting; and evolutionary theories of genomic imprinting. |
| Illustrations: |
halftones, line figures, tables |
| Publication: |
UK |
| Imprint: |
Oxford University Press |
| Returns: |
Returnable |
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