PROGRESS IN MEDICINAL CHEMISTRY by G. Lawton, David R. Witty ( 9780444530189 )

Item Details

Title:

PROGRESS IN MEDICINAL CHEMISTRY

Volume:

Volume 46

By:

G. Lawton, David R. Witty

Format:

Hardback

List price:

£140.00

Our price:

£126.00

Discount:

10% off

You save:

£14.00

ISBN 10:

0444530185

ISBN 13:

9780444530189

Availability:

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Publisher:

ELSEVIER SCIENCE & TECHNOLOGY

Pub. date:

8 April, 2008

Series:

Progress in Medicinal Chemistry

Pages:

420

Description:

Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. This title covers HIV integrase (discovery of the first-in-class inhibitor drug raltegravir), and 11-beta-Hydroxysteroid dehydrogenase (fresh approach to glucocorticoid regulation).

Synopsis:

Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, `validation' of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications)

Publication:

Imprint:

Elsevier Science Ltd

Returns:

Returnable

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