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Item Details
Title:
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INTRACELLULAR SIGNALING MEDIATORS IN THE CIRCULATORY AND VENTILATORY SYSTEMS
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By: |
Marc Thiriet |
Format: |
Hardback |
List price:
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£219.99 |
We currently do not stock this item, please contact the publisher directly for
further information.
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ISBN 10: |
1461443695 |
ISBN 13: |
9781461443698 |
Publisher: |
SPRINGER-VERLAG NEW YORK INC. |
Pub. date: |
25 September, 2012 |
Edition: |
2013 ed. |
Series: |
Biomathematical and Biomechanical Modeling of the Circulatory and 4 |
Pages: |
1079 |
Description: |
This book reviews signaling pathways in the regulation of circulatory and respiratory function, integrating biology, chemistry, and physics for a multidisciplinary view of physiological flows. It describes ion and molecular carriers and receptors. |
Synopsis: |
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis.Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. |
Illustrations: |
339 black & white tables, biography |
Publication: |
US |
Imprint: |
Springer-Verlag New York Inc. |
Returns: |
Returnable |
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