MENDELIAN RANDOMIZATION by Stephen Burgess, Simon G. Thompson ( 9781466573178 )

Item Details

Title:

MENDELIAN RANDOMIZATION
METHODS FOR USING GENETIC VARIANTS IN CAUSAL ESTIMATION

By:

Format:

Hardback

List price:	£69.99
We currently do not stock this item, please contact the publisher directly for further information.

ISBN 10:

1466573171

ISBN 13:

9781466573178

Publisher:

TAYLOR & FRANCIS INC

Pub. date:

23 February, 2015

Series:

Chapman & Hall/CRC Interdisciplinary Statistics

Pages:

224

Synopsis:

Presents the Terminology and Methods of Mendelian Randomization for Epidemiological Studies Mendelian randomization uses genetic instrumental variables to make inferences about causal effects based on observational data. It, therefore, can be a reliable way of assessing the causal nature of risk factors, such as biomarkers, for a wide range of disease outcomes. Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization spanning epidemiology, statistics, genetics, and econometrics. Although the book mainly focuses on epidemiology, much of the material can be applied to other areas of research. Through several examples, the first part of the book shows how to perform simple applied Mendelian randomization analyses and interpret their results. The second part addresses specific methodological issues, such as weak instruments, multiple instruments, power calculations, and meta-analysis, relevant to practical applications of Mendelian randomization.In this part, the authors draw on data from the C-reactive protein Coronary heart disease Genetics Collaboration (CCGC) to illustrate the analyses. They present the mathematics in an easy-to-understand way by using nontechnical language and reinforcing key points at the end of each chapter. The last part of the book examines the potential of Mendelian randomization in the future, exploring both methodological and applied developments. This book gives statisticians, epidemiologists, and geneticists the foundation to understand issues concerning the use of genetic variants as instrumental variables. It will get them up to speed in undertaking and interpreting Mendelian randomization analyses. Chapter summaries, paper summaries, web-based applications, and software code for implementing the statistical techniques are available on a supplementary website.

Illustrations:

22 black & white illustrations, 19 black & white tables

Publication:

Imprint:

CRC Press Inc

Returns:

Returnable

Some other items by this author:

DEFENCE APPLICATIONS OF MULTI-AGENT SYSTEMS (PB)

DEFENSE INDUSTRY APPLICATIONS OF AUTONOMOUS AGENTS AND MULTI-AGENT SYSTEMS (PB)

EFFECTIVE WEB PRESENCE SOLUTIONS FOR SMALL BUSINESSES (HB)

MANAGING INFORMATION TECHNOLOGY IN SMALL BUSINESS (PB)