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Item Details
| Title:
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REDUCING, REFINING AND REPLACING THE USE OF ANIMALS IN TOXICITY TESTING
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| By: |
Dave Allen (Editor), Mike Waters (Editor), Mike Waters |
| Format: |
Electronic book text |
| List price:
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£133.33 |
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We believe that this item is permanently unavailable, and so we cannot source
it.
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| ISBN 10: |
1849737924 |
| ISBN 13: |
9781849737920 |
| Publisher: |
ROYAL SOCIETY OF CHEMISTRY |
| Pub. date: |
31 October, 2013 |
| Series: |
Issues in Toxicology 19 |
| Pages: |
362 |
| Description: |
This thought-provoking book describes the ever-expanding "toolbox" of methods now available to reduce, refine, or replace animal usage in toxicity testing. |
| Synopsis: |
Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area. |
| Publication: |
UK |
| Imprint: |
Royal Society of Chemistry |
| Returns: |
Non-returnable |
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