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Item Details
| Title:
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THERAPEUTIC ANGIOGENESIS
FROM BASIC SCIENCE TO THE CLINIC |
| By: |
J.A. Dormandy (Editor), W.P. Dole (Editor), Gabor M. Rubanayi (Editor) |
| Format: |
Hardback |
| List price:
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£72.00 |
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We believe that this item is permanently unavailable, and so we cannot source
it.
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| ISBN 10: |
3540656936 |
| ISBN 13: |
9783540656937 |
| Publisher: |
SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG |
| Pub. date: |
1 September, 1999 |
| Series: |
Ernst Schering Foundation Symposium Proceedings v. 28 |
| Pages: |
197 |
| Description: |
Provides a comprehensive overview in the field of therapeutic angiogenesis, from the basic molecular aspects to clinical applications of various therapeutic principles (i.e. growth factor protein delivery, gene therapy and transmyocardial laser application). |
| Synopsis: |
Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e. g. , heart, brain, skeletal muscle) during criti- cal ischemia has prompted novel therapeutic strategies to stimulate/fa- cilitate angiogenesis and collateral formation in ischemic conditions ("therapeutic angiogenesis"). Therapeutic angiogenesis describes a strategy of inducing new col- lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en- hance tissue oxygen exchange. Naturally occurring growth factors (e. g. , FGFs, VEGFs) have been identified and demonstrated to induce new blood vessel formation in the adult organism. The therapeutic ap- plication of these growth factors has been demonstrated to enhance these natural processes and have been shown in a number of animal models to increase blood flow and oxygen exchange to ischemic tis- sues.Therapeutic angiogenesis therefore represents a new medical principle that is anticipated to be used as an adjunct or alternative to angioplasty and/or bypass surgery. A number of strategies have been proposed and tested to deliver growth factors. One strategy is the direct administration of the growth factor protein by intramuscular, intraarte- rial or intravenous delivery. |
| Illustrations: |
21 black & white illustrations, 10 black & white tables, biography |
| Publication: |
Germany |
| Imprint: |
Springer-Verlag Berlin and Heidelberg GmbH & Co. K |
| Returns: |
Returnable |
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