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Item Details
Title: RESTRICTION ENDONUCLEASES
By: A. Pingoud (Editor)
Format: Paperback

List price: £159.99


We currently do not stock this item, please contact the publisher directly for further information.

ISBN 10: 3642623247
ISBN 13: 9783642623240
Publisher: SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG
Pub. date: 21 September, 2012
Edition: Softcover reprint of the original 1st ed. 2004
Series: Nucleic Acids and Molecular Biology 14
Pages: 443
Synopsis: Restriction enzymes are highly specific nucleases which occur ubiquitously among prokaryotic organisms, where they serve to protect bacterial cells against foreign DNA. Many different types of restriction enzymes are known, among them multi-subunit enzymes which depend on ATP or GTP hydrolysis for target site location. The best known representatives, the orthodox type II restriction endonucleases, are homodimers which recognize palindromic sequences, 4 to 8 base pairs in length, and cleave the DNA within or immediately adjacent to the recognition site. In addition to their important biological role (up to 10 % of the genomes of prokaryotic organisms code for restriction/modification systems!), they are among the most important enzymes used for the analysis and recombination of DNA. In addition, they are model systems for the study of protein-nucleic acids interactions and, because of their ubiquitous occurence, also for the understanding of the mechanisms of evolution.
Illustrations: 16 Tables, black and white; XXVI, 443 p.
Publication: Germany
Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Returns: Returnable
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