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Item Details
| Title:
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ADENOVIRAL VECTORS FOR GENE THERAPY
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| By: |
David T. Curiel (Editor), Joanne Douglas (Editor) |
| Format: |
Hardback |
| List price:
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£185.00 |
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We believe that this item is permanently unavailable, and so we cannot source
it.
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| ISBN 10: |
0121995046 |
| ISBN 13: |
9780121995041 |
| Publisher: |
ELSEVIER SCIENCE PUBLISHING CO INC |
| Pub. date: |
28 May, 2002 |
| Pages: |
890 |
| Description: |
Covers topics that range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. |
| Synopsis: |
Gene therapy is gaining recognition as an exciting new therapeutic technique with great potential for the treatment of disease. Gene delivery vehicles, or vectors, based on the adenovirus are emerging as important tools in gene therapy. About one in ten people has, or will develop at some later stage, an inherited genetic disorder, and approximately 2800 specific conditions are known to be caused by defects (mutations) in just one of the patient's genes. To date, gene therapy techniques have not proved as successful in treating these disorders as originally hoped. Making gene therapy a successful endeavor will require careful research to improve traditional approaches and explore new ways to deal with genetic defects. One such innovative technique is the use of retroviruses and adenoviruses to deliver genes to cells without disrupting the cell's chromosomal configuration. Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents.The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials |
| Illustrations: |
Illustrations (some col.) |
| Publication: |
US |
| Imprint: |
Academic Press Inc |
| Returns: |
Returnable |
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