BASIC AND CLINICAL NEUROCARDIOLOGY by J.Andrew Armour (Editor), Jeffrey L. Ardell (Editor) ( 9780195141290 )

Item Details

Title:

BASIC AND CLINICAL NEUROCARDIOLOGY

By:

J.Andrew Armour (Editor), Jeffrey L. Ardell (Editor)

Format:

Hardback

List price:	£112.50
Our price:	£112.50

ISBN 10:

0195141296

ISBN 13:

9780195141290

Availability:

Usually dispatched within 3-5 days.

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Stock:

Currently 1item in stock

Publisher:

OXFORD UNIVERSITY PRESS INC

Pub. date:

1 April, 2004

Pages:

478

Description:

Neurocardiology is becoming increasingly relevant to the management of heart disease. This book presents novel concepts about how neurons from the level of the heart to the sensorium exert dynamic control over cardiac electrical and mechanical events over a lifetime. The book's major strength is in the tying together of basic scientific and clinical information on how the various components of neural control of the heart remodel during the evolution of cardiacpathologies - information essential for future development of integrated and targeted therapies.

Synopsis:

The progression of heart disease is associated with changes in the neurohumoral mechanisms that control cardiac function. The degree to which this neurohumoral remodelling occurs, even before overt signs of cardiac disease become manifest, is important for prognosis. To determine why some patients experience sudden death while others sustain life in the presence of severely compromised cardiac function, the neuronal control of cardiac electrical and mechanical events must be considered. Starting at the level of individual neurons and building upwards, this book describes the synergistic interactions that occur among intrathoracic and CNS feedback loops to permit precise control of regional cardiac behaviour. On this basic science foundation, subsequent clinical chapters explore the remodelling that occurs in this system with ageing, with the evolution of specific cardiac pathologies, and with the psychological concomitants of heart disease.Most importantly, these chapters provide unique insights into how specific therapies like beta-andrenergic receptor blockade not only affect cardiomyocytes directly but also mitigate the adverse neurohumoral changes that accompany disease processes, such as heart failure and essential hypertension. The paradigm advanced in this volume is that heart disease is a multifaceted phenomenon involving the interplay of neurohumoral, cardiomyocyte and structural elements, each of which depends on the other. With our cumulative understanding of these interdependent processes, new avenues for time-appropriate, targeted methods of treating heart diseases can be developed.

Illustrations:

numerous line drawings and 4 halftones

Publication:

Imprint:

Oxford University Press Inc

Returns:

Returnable