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Item Details
| Title:
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PHARMACOLOGY OF CYTOKINES
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| By: |
Alberto Mantovani, Charles A. Dinarello, Pietro Ghezzi |
| Format: |
Paperback |
| List price:
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£140.00 |
| Our price: |
£122.50 |
| Discount: |
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| You save:
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£17.50 |
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| ISBN 10: |
0198500424 |
| ISBN 13: |
9780198500421 |
| Availability: |
Usually dispatched within 1-3 weeks.
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rates
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| Stock: |
Currently 0 available |
| Publisher: |
OXFORD UNIVERSITY PRESS |
| Pub. date: |
7 September, 2000 |
| Pages: |
344 |
| Description: |
Cytokines are the 'words' of immunity, serving as mediators within and outside the immune system. There is tremendous interest in their exploitation as therapeutic tools in diverse human diseases and considerable effort has been made to understand and utilize their pharmacology. This book examines this pharmacology, from development and characterization of simple chemicals and their mechanism of action to the use of biotechnology- based approaches. The book putscytokines and their pharmacology in context and examines their involvement in individual organ-disease systems. |
| Synopsis: |
Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role in homeostasis and in host defence and are involved in such inflammatory and autoimmune diseases such as rheumatoid arthritis as well as infectious diseases such as HIV infection and septic shock. Modulation of the production and action of cytokines, as well as their exploitation as therapeutic agents, has been the object of intense and competitive research. The pharmacology of cytokines is an exploding area which is entering the clinical arena. This book gives an overview of cytokine research and describes the various approaches that have been taken to develop the pharmacology of these novel mediators. Within the framework of the immunobiology of cytokines, the book examines the interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products .In addition to examining individual agents and approaches, it reviews the pathophysiology of individual body systems and analysis specific contexts for the pathophysiology of these mediators as well as pharmacological approaches for their control. |
| Publication: |
UK |
| Imprint: |
Oxford University Press |
| Returns: |
Returnable |
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