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Item Details
Title:
GENETIC EFFECTS ON ENVIRONMENTAL VULNERABILITY TO DISEASE
STATE OF THE ART AND FUTURE DIRECTIONS
By:
Sir Michael Rutter (Editor)
Format:
Hardback
List price:
£88.95
Our price:
£80.06
Discount:
10
% off
You save:
£8.89
ISBN 10:
047077780X
ISBN 13:
9780470777800
Availability:
Usually dispatched within 1-3 weeks.
Delivery rates
Stock:
Currently
0
available
Publisher:
JOHN WILEY AND SONS LTD
Pub. date:
6 June, 2008
Series:
Novartis Foundation Symposia 293
Pages:
232
Description:
Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment.
Synopsis:
Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss:* How epidemiological cohort studies can better integrate physiological (mechanistic) measures;* How best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms;* How gene hunters can benefit from recruiting samples selected for known exposures;* How environmental pathogens can be used as tools for gene hunting;* How to deal with potential spurious (statistical) interactions, and* How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).
Illustrations:
Illustrations
Publication:
US
Imprint:
Wiley-Blackwell
Returns:
Returnable
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