PRECLINICAL DRUG DEVELOPMENT by Mark Rogge (Editor), David R. Taft (Editor) ( 9781420084726 )

Item Details

Title:

PRECLINICAL DRUG DEVELOPMENT

By:

Mark Rogge (Editor), David R. Taft (Editor)

Format:

Hardback

List price:

£185.00

Our price:

£166.50

Discount:

10% off

You save:

£18.50

ISBN 10:

1420084720

ISBN 13:

9781420084726

Availability:

Usually dispatched within 3-5 days.

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Stock:

Currently 1item in stock

Publisher:

TAYLOR & FRANCIS INC

Pub. date:

25 September, 2009

Edition:

2nd Revised edition

Series:

Drugs and the Pharmaceutical Sciences 187

Pages:

376

Description:

Preclinical Drug Development

Synopsis:

Preclinical Drug Development, Second Edition discusses the broad and complicated realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology to industry trends and regulatory expectations to requirements that support clinical trials. Highlights of the Second Edition include: * Pharmacokinetics * Modeling and simulation * Formulation and routes of administration * Toxicity evaluations * The assessment of drug absorption and metabolism * Interspecies scaling * Lead molecule selection and optimization via profiling * Screening using in silico and in vitro toxicity evaluations The book also includes case studies on preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development, a review of ICH preclinical guidelines, and experimental methods used to study membrane drug transport and metabolism. This guide is a fundamental resource for medicinal chemists, biologists, and other specialists in the drug development sciences.

Illustrations:

58 black & white illustrations, 16 colour illustrations

Publication:

Imprint:

Informa Healthcare

Returns:

Returnable

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