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Item Details
| Title:
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A-LACTALBUMIN
IN MOLECULAR ANATOMY AND PHYSIOLOGY OF PROTEINACEOUS MACHINES |
| By: |
Eugene A. Permyakov |
| Format: |
Hardback |
| List price:
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£163.99 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
1594541078 |
| ISBN 13: |
9781594541070 |
| Publisher: |
NOVA SCIENCE PUBLISHERS INC |
| Pub. date: |
1 December, 2004 |
| Pages: |
136 |
| Synopsis: |
Small acidic protein a-lactalbumin, one of the major protein components of milk, is one of the most extensively investigated Ca2+-binding proteins, which does not belong to the EF-hand family of calcium-binding proteins. It serves as a model for studies of the mechanisms of protein stability, folding and unfolding. a-Lactalbumin acts as a regulatory subunit of galactosyltransferase in lactose synthase, which catalyses the synthesis of lactose from UDP-galactose and glucose. It represents a classical example of molten globule state at acidic pH and in its apo-form at elevated temperatures. Three-dimensional structures of several ?-lactalbumins are determined. The protein possesses a single strong Ca2+-binding site, which binds Mg2+, Mn2+, Na+, and K+ as well, and several distinct Zn2+-binding sites. The binding of cations to the Ca2+-site increases protein stability against action of heat, various denaturing agents and proteases, while the binding of Zn2+ to the Ca2+-saturated protein decreases its stability and causes its aggregation. ?-Lactalbumin interacts with membranes, proteins, peptides and low molecular weight substrates and products.These interactions are modulated by the binding of metal cations to a-lactalbumin. a-Lactalbumin forms amyloid fibrils at low pH values and some folding variants of a-lactalbumin demonstrate bactericidal activity and some of them cause apoptosis of tumour cells. Thus, ?-lactalbumin is a metal binding protein, the function of which depends on its environment: it takes part in lactose synthesis in the mammary gland and could be important for lowering the incidence of cancer and various infections in breast-fed children. |
| Illustrations: |
Illustrations (some col.) |
| Publication: |
US |
| Imprint: |
Nova Science Publishers Inc |
| Returns: |
Returnable |
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