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Item Details
| Title:
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MULTI-DRUG RESISTANCE IN CANCER
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| Volume: |
2010 |
| By: |
Jun Zhou (Editor) |
| Format: |
Hardback |
| List price:
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£129.99 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
1607614154 |
| ISBN 13: |
9781607614159 |
| Publisher: |
HUMANA PRESS INC. |
| Pub. date: |
1 November, 2009 |
| Series: |
Methods in Molecular Biology No. 596 |
| Pages: |
492 |
| Description: |
The efficacy of chemotherapeutic management of cancer is often severely limited. This book provides comprehensive reviews of multidrug resistance mechanisms. It includes up-to-date techniques for detection and imaging of drug transporters. |
| Synopsis: |
Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression.In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface...v Contributors...ix 1 Multidrug Resistance in Cancer ...1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets ... |
| Illustrations: |
63 black & white illustrations, 4 colour illustrations, 32 black & white |
| Publication: |
US |
| Imprint: |
Humana Press Inc. |
| Returns: |
Returnable |
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