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Item Details
| Title:
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MACROCYCLES IN DRUG DISCOVERY
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| By: |
Jeremy Levin (Editor), David P. Rotella, Karl-Heinz Altmann |
| Format: |
Electronic book text |
| List price:
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£175.00 |
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We believe that this item is permanently unavailable, and so we cannot source
it.
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| ISBN 10: |
1782623116 |
| ISBN 13: |
9781782623113 |
| Publisher: |
ROYAL SOCIETY OF CHEMISTRY |
| Pub. date: |
3 October, 2014 |
| Series: |
RSC Drug Discovery 40 |
| Description: |
This book will review macrocycles in drug discovery and will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia. |
| Synopsis: |
The medicinal chemistry of natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, is now informing the design of fully synthetic drug candidates against a variety of targets. Furthermore, as more and more non-classical drug targets, such as protein-protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are becoming increasingly important as they offer a way to provide drug-protein interactions that cover a larger surface area than traditional small molecules. An indication of this growing importance is the fact that several companies now provide libraries of macrocyclic molecules produced by proprietary chemical technology to use for lead generation. A variety of macrocyclic natural products have become important drugs or have been identified as leads to marketed drugs. This book reviews macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry.It discusses these compounds in the context of their broad chemotype as compounds composed of large rings. Providing a wide reaching review of this important area in a single volume, this book is of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia. |
| Publication: |
UK |
| Imprint: |
Royal Society of Chemistry |
| Returns: |
Non-returnable |
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