PROTEIN EXPRESSION IN DOWN SYNDROME BRAIN by Gert Lubec (Editor) ( 9783211837320 )

Item Details

Title:

PROTEIN EXPRESSION IN DOWN SYNDROME BRAIN

By:

Format:

Hardback

List price:	£183.50
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ISBN 10:

3211837329

ISBN 13:

9783211837320

Publisher:

SPRINGER VERLAG GMBH

Pub. date:

15 October, 2001

Edition:

Softcover Reprint of the Origi ed.

Series:

Journal of Neural Transmission. Supplementa SUPP 61

Pages:

374

Description:

Presents research work and opinions on Down syndrome. This book focuses on the molecular biology of the Down syndrome brain at the protein level, rather than at nucleic acid level. The studies used fetal brains in which no neurodegeneration was found and characterized proteins by two-dimensional gel electrophoresis and mass spectrometry.

Synopsis:

When we worked on Down Syndrome brain in the past we have been focus- ing on adult brain. This was a major step forwards as most work on Down Syndrome was carried out on fibroblasts or other tissues and, moreover, we introduced proteomics to identify and quantify brain protein expression. We considered evaluation of brain protein expression in Down Syndrome brain by and by more important than gene hunting at the nucleic acid level realiz- ing the long unpredictable way from RNA to protein. The availability of fetal samples along with the proteomic appproach stimulated and reinforced studies on Down Syndrome brain. And indeed, it was found out that some observations on aberrant protein expression in adult Down Syndrome brain could not be verified in the fetal samples indi- cating that neurodegeneration in adult Down Syndrome brain may have been responsible rather than trisomy 21. Using brains from the early second trimester of gestation led to the generation of a series of clues for the under- standing of aberrant wiring of the brain in Down Syndrome and enabled the determination of altered key functions in early life; e. g. undetectably low drebrin was observed in Down Syndrome cortex, an integral constituent and marker for dendritic spines, main effectors of cross-talk between neurons.In addition, evaluation of the nature of the neuronal deficits in terms of neuro- transmission markers could be established as well as neuronal density in fetal Down Syndrome cortex.

Illustrations:

biography

Publication:

Austria

Imprint:

Springer Verlag GmbH

Returns:

Returnable

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