ASYMMETRIC SYNTHESIS OF BIOACTIVE LACTONES AND THE DEVELOPMENT OF A CATALYTIC ASYMMETRIC SYNTHESIS OF A-ARYL KETONES by Robert Doran ( 9783319205434 )

Item Details

Title:

ASYMMETRIC SYNTHESIS OF BIOACTIVE LACTONES AND THE DEVELOPMENT OF A CATALYTIC ASYMMETRIC SYNTHESIS OF A-ARYL KETONES

By:

Format:

Hardback

List price:	£109.99
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ISBN 10:

3319205439

ISBN 13:

9783319205434

Publisher:

SPRINGER INTERNATIONAL PUBLISHING AG

Pub. date:

25 June, 2015

Edition:

2015 ed.

Series:

Springer Theses

Pages:

202

Synopsis:

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.

Illustrations:

3 Illustrations, color; 255 Illustrations, black and white; XXI, 202 p. 258

Publication:

Switzerland

Imprint:

Springer International Publishing AG

Returns:

Returnable

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