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Item Details
| Title:
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REGULATION OF MEMBRANE NA+-K+ ATPASE
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| Volume: |
2016 |
| By: |
Sajal Chakraborti (Editor), Naranjan S. Dhalla (Editor) |
| Format: |
Hardback |
| List price:
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£179.99 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
3319247484 |
| ISBN 13: |
9783319247489 |
| Publisher: |
SPRINGER INTERNATIONAL PUBLISHING AG |
| Pub. date: |
16 December, 2015 |
| Series: |
Advances in Biochemistry in Health and Disease 15 |
| Pages: |
436 |
| Synopsis: |
Na+-K+ ATPase or Na-pump ATPase, a member of "P"-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it's alpha- and ss- subunits. At present four different alpha- (alpha-1,alpha-2,alpha-3 and alpha-4) and three ss- (ss-1, ss-2, and ss-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of alpha- and ss- subunits leading to an increased expression in the level of Na+-pump.Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra ne domain adjacent to the isoform(s) of alpha-ss subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled "Regulation of Membrane Na+-K+ ATPase" for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease. |
| Illustrations: |
56 black & white illustrations, 44 colour illustrations, 16 black & white |
| Publication: |
Switzerland |
| Imprint: |
Springer International Publishing AG |
| Returns: |
Non-returnable |
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