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Item Details
| Title:
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CHEMOKINE ROLES IN IMMUNOREGULATION AND DISEASE
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| By: |
P.M. Murphy (Editor), Richard Horuk (Editor) |
| Format: |
Hardback |
| List price:
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£139.99 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
3540402217 |
| ISBN 13: |
9783540402213 |
| Publisher: |
SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG |
| Pub. date: |
23 October, 2003 |
| Edition: |
2004 ed. |
| Series: |
Ernst Schering Foundation Symposium Proceedings 45 |
| Pages: |
160 |
| Synopsis: |
In autumn 2002, the Ernst Schering Research Foundation Workshop sponsored the 45th in its series of conferences devoted to emerging areas in basic and applied biomedical research. These conferences bring together a critical mass of top scientists working in an impor- tant area in an intimate setting that fosters the free exchange of knowledge and ideas. In this spirit, Workshop 45 assembled leaders in the field of chemokines - hemotactic cytokines that coordinate leukocyte trafficking - amid the scenic vineyards and wineries of Napa Valley, to discuss the latest concepts of how these molecules regulate the immune response and disease. Chemokines were se- lected as a conference topic because they have revitalized the study of leukocyte trafficking and are widely considered to be potential new targets for drug development, in diseases ranging from acute in- flammation and autoimmunity to HIV and cancer. Discovered in the 1980s, the chemokine superfamily currently has 43 human members, making it the largest subset of cytokines.Mem- bers are defined by conserved sequences and a common three-di- mensional fold, and can be divided into two major functional groups - homeostatic and inflammatory - depending on whether they are produced constitutively, and thereby control basal lymphocyte traf- ficking, or whether they must be induced, for example by pathogens or injury, and thereby control deployment of effector leukocytes in emergencies. |
| Illustrations: |
4 Tables, black and white; XV, 160 p. |
| Publication: |
Germany |
| Imprint: |
Springer-Verlag Berlin and Heidelberg GmbH & Co. K |
| Returns: |
Returnable |
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