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Item Details
| Title:
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RECENT PROGRESS IN THE GENETIC EPIDEMIOLOGY OF CANCER
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| By: |
Henry T. Lynch (Editor), Petre Tautu (Editor) |
| Format: |
Paperback |
| List price:
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£96.50 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
3540530223 |
| ISBN 13: |
9783540530220 |
| Publisher: |
SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG |
| Pub. date: |
29 January, 1991 |
| Pages: |
162 |
| Description: |
The genetic epidemiology of various rare and common tumours is investigated in a study which offers advice on statistical and methodological approaches to experimental design. Information on computer models for data storage and analysis is also provided. |
| Synopsis: |
The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C. King et al. in 1984. 1t pinpoints the fundamental genetic hypothesis, namely, the existence of an inherited condition that predisposes an individual to a specific disease, and the corresponding subject ofinvestigation, the family. Thus, the genetic epidemiological situation consists of three basic elements: (l) the genealogical structure, (2) the mode of inherit- ance (i. e. , the "genetic model") for the trait of interest, and (3) the observable phenotypes of susceptibility. It is clear that genetic epidemiology is a research field posi- tioned at the intersection of molecular genetics, population gen- etics, and clinical genetics. Perhaps the genealogical tree should be its central element: it evidences something forgotten in mole- cular genetics, namely the relationships, and associations with probabilistic and statistical concepts from population genetics. It offers a structure and a "history" for those clinicians studying familial diseases who are searching for genetic determinants of susceptibility. The genetic epidemiologist begins his analysis with a point on this genealogical tree, namely the proband, and attempts to carry out (nonrandom) "ascertainment sampling" by using a strategy that depends on the form and dimension (extended pedigrees versus nuclear families) of the tree. |
| Illustrations: |
16 Tables, black and white; 7 Illustrations, black and white; XI, 162 p. 7 |
| Publication: |
Germany |
| Imprint: |
Springer-Verlag Berlin and Heidelberg GmbH & Co. K |
| Returns: |
Returnable |
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