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Item Details
| Title:
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CLOSTRIDIUM DIFFICILE
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| By: |
K. Aktories (Editor), T.D. Wilkins (Editor) |
| Format: |
Paperback |
| List price:
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£149.00 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
3642086683 |
| ISBN 13: |
9783642086687 |
| Publisher: |
SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG |
| Pub. date: |
19 October, 2010 |
| Edition: |
Softcover reprint of hardcover 1st ed. 2000 |
| Series: |
Current Topics in Microbiology and Immunology 250 |
| Pages: |
150 |
| Synopsis: |
Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes. |
| Illustrations: |
IX, 150 p. |
| Publication: |
Germany |
| Imprint: |
Springer-Verlag Berlin and Heidelberg GmbH & Co. K |
| Returns: |
Returnable |
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