INTRACELLULAR TRAFFIC AND NEURODEGENERATIVE DISORDERS by Peter H. George-Hyslop (Editor), William C. Mobley (Editor) ( 9783642099724 )

Item Details

Title:

INTRACELLULAR TRAFFIC AND NEURODEGENERATIVE DISORDERS

By:

Peter H. George-Hyslop (Editor), William C. Mobley (Editor)

Format:

Paperback

List price:	£183.50
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ISBN 10:

3642099726

ISBN 13:

9783642099724

Publisher:

SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG

Pub. date:

24 November, 2010

Edition:

Softcover reprint of hardcover 1st ed. 2009

Series:

Research and Perspectives in Alzheimer's Disease

Pages:

184

Description:

Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.

Synopsis:

Neurodegenerative disorders are common and devastating. Rationally, the most effective treatments will target pathogenetic mechanisms. While alternative - proaches, based on alleviating the symptoms of patients with Alzheimer disease, Parkinson disease, Huntington disease, prion disorders or amyotrophic lateral sc- rosis, can be expected to reduce suffering, studies of pathogenesis of these a- related disorders will be most important for enabling early diagnosis and the creation of preventative and curative treatments. It is in this context that a recent IPSEN rd meeting (The 23 Colloque Medecine ' et Recherche, April 28, 2008) focused on a role for disruption of intracellular traf?cking in neurodegenerative disorders. The meeting captured emerging insights into pathogenesis from disrupted traf?cking and processing of proteins implicated in age-related degeneration. Protein folding, traf?cking and signaling were the principal topics covered at the meeting. Importantly, the presenters pointed to the importantly intersection of these themes. While the proteolytic processing of APP into its toxic product, the A? peptide, is an intensive focus of work in many laboratories, it is only relatively recently that investigators have begun to examine in depth the cellular compartments and traf?cking events that mediate APP processing and how derangement of tr- ?cking pathways could impact them.

Illustrations:

10 Tables, black and white; 25 Illustrations, color; 11 Illustrations,

Publication:

Germany

Imprint:

Springer-Verlag Berlin and Heidelberg GmbH & Co. K

Returns:

Returnable

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INTRACELLULAR TRAFFIC AND NEURODEGENERATIVE DISORDERS (HB)