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Item Details
| Title:
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PHOSPHODIESTERASES AS DRUG TARGETS
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| By: |
Sharron H. Francis (Editor), Marco Conti (Editor), Miles D. Houslay (Editor) |
| Format: |
Hardback |
| List price:
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£279.99 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
3642179681 |
| ISBN 13: |
9783642179686 |
| Publisher: |
SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG |
| Pub. date: |
31 July, 2011 |
| Edition: |
2011 |
| Series: |
Handbook of Experimental Pharmacology 204 |
| Pages: |
522 |
| Description: |
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Along with its coverage of fresh and emerging ideas in this key field, the book examines all the major concepts related to the design and use of PDE inhibitors. |
| Synopsis: |
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors. |
| Illustrations: |
XVIII, 522 p. |
| Publication: |
Germany |
| Imprint: |
Springer-Verlag Berlin and Heidelberg GmbH & Co. K |
| Returns: |
Returnable |
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