GENETICS OF IMMUNOLOGICAL DISEASES by Beverly Mock (Editor), Michael Potter (Editor) ( 9783642500619 )

Item Details

Title:

GENETICS OF IMMUNOLOGICAL DISEASES

By:

Beverly Mock (Editor), Michael Potter (Editor)

Format:

Paperback

List price:	£76.50
We currently do not stock this item, please contact the publisher directly for further information.

ISBN 10:

3642500617

ISBN 13:

9783642500619

Publisher:

SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG

Pub. date:

25 May, 2012

Edition:

Softcover reprint of the original 1st ed. 1988

Series:

Current Topics in Microbiology and Immunology 137

Pages:

335

Synopsis:

The development of innovative molecular techniques such as pulse-field gel electro- phoresis, cDNA subtraction libraries and chromosome hopping libraries coupled with the increasing popularity in the prospect of sequencing mammalian genomes, has triggered a resurgence of interest in finding and characterizing genes that playa role in modifying immune processes and diseases. Genetically defined strains of mice (e. g. , inbred strains and recently derived stocks of wild mice) provide ideal models for examining the genetic control of diseases as a result of their syntenic relationship with man in genetic composition as well as linkage conserva- tion. Due to the relative ease of producing a specific genotype via appropriate breeding schedules, murine models may provide the only hope for unravelling those complex disease processes under mUltigenic control. This issue of CTMI is a collection of papers on the characterization and mapping of genes involved in mutations and dysregulated immune responses which produce disease phenotypes. These papers were presented at a workshop which was devoted to examining reverse genetic approaches at localizing, cloning and characterizing genes involved in a variety of developmental, autoimmune, neoplastic and infectious disease processes. In the first of three sections, a series of papers outline the most currently used methods of mapping and isolating genes whose products are unknown. The papers, following, are devoted to specific gene systems whose dysregulation is likely to produce mutant or disease phenotypes.

Illustrations:

44 Illustrations, black and white; XI, 335 p. 44 illus.

Publication:

Germany

Imprint:

Springer-Verlag Berlin and Heidelberg GmbH & Co. K

Returns:

Returnable

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