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Item Details
Title: TOLL-LIKE RECEPTORS IN INFLAMMATION
By: Luke A. J. O'Neill (Editor), Elisabeth Brint (Editor)
Format: Hardback

List price: £166.50


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ISBN 10: 3764372850
ISBN 13: 9783764372859
Publisher: BIRKHAUSER VERLAG AG
Pub. date: 9 December, 2005
Edition: 2005 ed.
Series: Progress in Inflammation Research
Pages: 246
Description: A repertoire of ten TLRs mediate the response to microbes that infect mammals. This volume covers the understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their role in inflammatory diseases, this book is of interest to researchers working in inflammation and immunology.
Synopsis: A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology.
Illustrations: 4 Tables, black and white; XII, 246 p.
Publication: Switzerland
Imprint: Birkhauser Verlag AG
Returns: Returnable
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