IG SUPERFAMILY MOLECULES IN THE NERVOUS SYSTEM by Peter Sonderegger ( 9789057024115 )

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Title:

IG SUPERFAMILY MOLECULES IN THE NERVOUS SYSTEM

By:

Peter Sonderegger

Format:

Hardback

List price:

£260.00

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£234.00

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10% off

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£26.00

ISBN 10:

905702411X

ISBN 13:

9789057024115

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Publisher:

TAYLOR & FRANCIS LTD

Pub. date:

18 January, 1999

Pages:

328

Description:

This work summarizes the molecular features and some of the cellular functions of Ig superfamily cell surface molecules. It includes information on the molecular structure of the immunoglobulin fold, the common domain of these proteins.

Synopsis:

A vast number of neural cell surface glycoproteins belonging to the immunoglobulin superfamily have been isolated over the past two decades. In functional studies, many of them have been shown to confer adhesive properties to cells and to play an important role in developmental processes such as cell migration and axon outgrowth. Recent observations implicate Ig superfamily adhesion molecules in the regulation of activity-dependent synaptic plasticity, in regeneration after neural trauma, as well as in the pathogenesis of malformations in the developing nervous systems. This book summarizes the molecular features and some of the cellular functions of this important class of cell surface molecules. It includes detailed information on the molecular structure of the immunoglobulin fold, the common domain of these proteins, the molecular interactions between various neural Ig superfamily members and their role in signal transduction, as well as the role of Ig superfamily adhesion molecules in axon guidance during both vertebrate and invertebrate neurogenesis.Recent observations on a role for these molecules in activity-dependent synaptic plasticity and in the regeneration of injured axons in the peripheral and central nervous system are described. A discussion on the connection between Ig superfamily adhesion molecules and medical genetics is also provided.

Illustrations:

illustrations

Publication:

Imprint:

Taylor & Francis Ltd

Returns:

Returnable

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