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Item Details
| Title:
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CALCIUM ENTRY BLOCKERS IN CARDIOVASCULAR AND CEREBRAL DYSFUNCTIONS
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| By: |
T. Godfraind (Editor), A.G. Herman (Editor), D. Wellens (Editor) |
| Format: |
Paperback |
| List price:
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£54.99 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
9400960352 |
| ISBN 13: |
9789400960350 |
| Publisher: |
SPRINGER |
| Pub. date: |
4 November, 2011 |
| Edition: |
Softcover reprint of the original 1st ed. 1984 |
| Series: |
Developments in Cardiovascular Medicine 40 |
| Pages: |
325 |
| Synopsis: |
2 The free internal Ca+ concentration in human red cells is set according to the leak- 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca- 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady- 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con- 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec- 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra- tion is ;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower). |
| Illustrations: |
325 p. |
| Publication: |
Netherlands |
| Imprint: |
Springer |
| Returns: |
Returnable |
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