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Item Details
| Title:
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MECHANISTIC ENZYMOLOGY AND DRUG DESIGN
CLINICALLY USED ENZYME INHIBITORS |
| By: |
John F. Honek, Zhengding Su, David E. Thurston |
| Format: |
Hardback |
| List price:
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£79.95 |
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We believe that this item is permanently unavailable, and so we cannot source
it.
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| ISBN 10: |
1849730156 |
| ISBN 13: |
9781849730150 |
| Publisher: |
ROYAL SOCIETY OF CHEMISTRY |
| Pub. date: |
31 March, 2016 |
| Series: |
RSC Drug Discovery |
| Pages: |
250 |
| Description: |
Surveys enzyme targets that have successfully been used to develop clinically-utilized drugs and describes how these drugs inhibit these particular enzymes. |
| Synopsis: |
What drugs are available that specifically target enzymes in humans and pathogens, and what new ones are currently in early clinical testing for new target enzymes? Currently there are no books that address this aspect of successful drug design from a survey of the six classes of enzyme categories. Mechanistic Enzymology and Drug Design: Clinically Used Enzyme Inhibitors surveys enzyme targets that have successfully been used to develop clinically-utilized drugs and describes in detail how these drugs inhibit these particular enzymes. It also presents the underlying principles that medicinal chemists can use to design other inhibitors for new targets, keeping in mind the mechanism of the enzyme. It is a systematic survey of the six Enzyme Commission (EC) classes of enzymes (EC1: Oxidoreductases; EC2: Transferases; EC3:Hydrolases; EC4: Lyases; EC5: Isomerases; EC6:Ligases) and explains how various clinically-utilized drugs inhibit these various classes. The book focuses on enzyme mechanisms, and introduces key drugs that target each type and subtype of enzyme, and describes, with figures and arrow-pushing diagrams, how these inhibitors work.Diagrams of the active site and how the inhibitor binds to the enzyme are shown where applicable. The book will appeal to medicinal chemists, pharmacy students and graduate students (organic, biochemistry) as well as advanced undergraduate students. It is also aimed at professionals including faculty members, libraries, industrial scientists such as biochemists and chemists and anyone working in the pharmaceutical industry. |
| Illustrations: |
200 black & white halftones |
| Publication: |
UK |
| Imprint: |
Royal Society of Chemistry |
| Returns: |
Returnable |
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