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Item Details
| Title:
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REDIRECTION OF TH1 AND TH2 RESPONSES
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| By: |
Robert L. Coffman (Editor), Sergio Romagnani (Editor) |
| Format: |
Paperback |
| List price:
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£76.50 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
3662097117 |
| ISBN 13: |
9783662097113 |
| Publisher: |
SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG |
| Pub. date: |
15 December, 1998 |
| Edition: |
Softcover reprint of the original 1st ed. 1999 |
| Series: |
Current Topics in Microbiology and Immunology 238 |
| Pages: |
150 |
| Synopsis: |
It has been 12 years since the first proposal was made to sub- divide mouse CD4 I T cell clones into Th I and Th2 subsets, based on their differences in cytokine production, and 7 years since the first clear demonstration of a similar dichotomy among human T cell clones. In the ensuing period, it has been realized that inappropriate development of Th I or Th2 responses are important features of many immunological and infectious dis- eases. Perhaps the first group of diseases to be understood in terms of preferential Th subset activation were allergic diseases (see PARRONC'HI et aI. , this volume). Several of the major, co- ordinately regulated, features of allergy, including IgE, eosino- philia and mastocytosis, were found to be stimulated by the T- specific cytokines I L-4 and IL-5 and inhibited by the Th I cyto- kine, IFN-. This suggested that the presence and severity of al- lergic responses reflected the relative numbers of Th I and Th2 cells specific for the offending allergen.Similarly, the very dif- ferent consequences of protective Th I and nonprotective Th2 responses to a number of intracellular pathogens have been re- cognized for some time (see TRINCHIERI and SCOTI, and COFF- MAN et aI. , this volume). |
| Illustrations: |
10 Tables, black and white; 8 Illustrations, black and white; IX, 150 p. 8 |
| Publication: |
Germany |
| Imprint: |
Springer-Verlag Berlin and Heidelberg GmbH & Co. K |
| Returns: |
Returnable |
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