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Item Details
| Title:
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PROTEIN MISFOLDING IN NEURODEGENERATIVE DISEASES
MECHANISMS AND THERAPEUTIC STRATEGIES |
| By: |
Robert D. E. Sewell (Editor) |
| Format: |
Electronic book text |
| List price:
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£126.00 |
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We believe that this item is permanently unavailable, and so we cannot source
it.
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| ISBN 10: |
1420007149 |
| ISBN 13: |
9781420007145 |
| Publisher: |
TAYLOR & FRANCIS INC |
| Pub. date: |
3 December, 2007 |
| Series: |
Enzyme Inhibitors Series |
| Pages: |
592 |
| Synopsis: |
Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS. A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer's, Parkinson's, Huntington's, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases. |
| Illustrations: |
7 Halftones, black and white; 18 Tables, black and white; 80 Illustrations, |
| Publication: |
US |
| Imprint: |
CRC Press Inc |
| Returns: |
Non-returnable |
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