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Item Details
| Title:
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CANCER DRUG RESISTANCE
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| By: |
Beverly A. Teicher (Editor) |
| Format: |
Hardback |
| List price:
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£199.99 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
1588295303 |
| ISBN 13: |
9781588295309 |
| Publisher: |
HUMANA PRESS INC. |
| Pub. date: |
9 March, 2006 |
| Series: |
Cancer Drug Discovery and Development |
| Pages: |
617 |
| Description: |
Helps in understanding the complex interactions between host, tumor and cytotoxic or immunomodulatory agents. This work addresses the resistance of solid tumors to anticancer therapeutics by considering mechanisms that involve alterations in genetics and epigenetics, cellular biochemistry, and properties related to physiology of solid tumor mass. |
| Synopsis: |
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. The highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin. |
| Illustrations: |
biography |
| Publication: |
US |
| Imprint: |
Humana Press Inc. |
| Returns: |
Returnable |
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