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Item Details
| Title:
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CANCER THERAPEUTICS
EXPERIMENTAL AND CLINICAL AGENTS |
| By: |
Beverly A. Teicher (Editor) |
| Format: |
Paperback |
| List price:
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£199.99 |
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We currently do not stock this item, please contact the publisher directly for
further information.
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| ISBN 10: |
1617370460 |
| ISBN 13: |
9781617370465 |
| Publisher: |
HUMANA PRESS INC. |
| Pub. date: |
28 October, 2010 |
| Edition: |
Softcover reprint of the original 1st ed. 1997 |
| Series: |
Cancer Drug Discovery and Development |
| Pages: |
451 |
| Synopsis: |
Cancer drug discovery has been and continues to be a process of ingenuity, serendip- ity, and dogged determination. In an effort to develop and discover better therapies against cancer, investigators all over the world have increased our knowledge of cell biology, biochemistry, and molecular biology. The goal has been to define therapeuti- cally exploitable differences between normal and malignant cells. The result has been an increased understanding of cellular and whole-organism biology and an increased respect for the flexibility and resiliency ofbiologically systems. Thus, as some new therapeutic targets have been defined and new therapeutic strategies have been attempted, so have some new biological hurdles resulting from tumor evasion of the intended therapeutic attack been discovered. Historically, anticancer drugs have originated from all available chemical sources. Synthetic molecules from the chemical industry, especially dyestuffs and warfare agents, and natural products from plants, microbes, and fungi have all been potential sources of pharmaceuticals, including anticancer agents.There is no shortage of molecules; the challenge has been and continues to be methods of identifying molecules that have the potential to be therapeutically important in human malignant disease. "Screening" remains the most important and most controversial method in cancer drug discovery. In vitro screens have generally focused on cytotoxicity and have identified several highly cytotoxic molecules. Other endpoints available in vitro are inhibition of proliferation, 3 inhibition of [ H]thymidine incorporation into DNA and various viability assays, based most frequently on dye exclusion or metabolism. |
| Illustrations: |
7 black & white illustrations, biography |
| Publication: |
US |
| Imprint: |
Humana Press Inc. |
| Returns: |
Returnable |
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Ramadan and Eid al-Fitr
A celebratory, inclusive and educational exploration of Ramadan and Eid al-Fitr for both children that celebrate and children who want to understand and appreciate their peers who do.
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