Title:
|
PROTEOPATHIC SEEDS AND NEURODEGENERATIVE DISEASES
|
By: |
Mathias Jucker (Editor), Yves Christen (Editor) |
Format: |
Paperback |
![](/Images/divider_itemdetail_1a.gif)
List price:
|
£119.99 |
We currently do not stock this item, please contact the publisher directly for
further information.
|
|
|
|
|
ISBN 10: |
3642446965 |
ISBN 13: |
9783642446962 |
Publisher: |
SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG |
Pub. date: |
14 February, 2013 |
Edition: |
2013 ed. |
Series: |
Research and Perspectives in Alzheimer's Disease |
Pages: |
156 |
Description: |
This book details the latest research on prion diseases and presents developing therapies. It includes contributions from Nobel Laureates Eric Kandel and Stanley Prusiner. |
Synopsis: |
The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer's disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ? |
Illustrations: |
4 Tables, black and white; XII, 156 p. |
Publication: |
Germany |
Imprint: |
Springer-Verlag Berlin and Heidelberg GmbH & Co. K |
Returns: |
Returnable |