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Item Details
Title: INTEGRINS AND ICAM-1 IN IMMUNE RESPONSES
Volume: v. 50
By: H. Renz, N. Hogg (Editor)
Format: Hardback

List price: £76.10


We currently do not stock this item, please contact the publisher directly for further information.

ISBN 10: 380555429X
ISBN 13: 9783805554299
Publisher: S KARGER AG
Pub. date: 1 October, 1991
Series: Chemical Immunology & Allergy 50
Pages: 168
Description: An overview of the structure and function of a number of integrins and of intercellular adhesion molecule-1(ICAM-1). Topics covered include the regulation of leukocyte integrin function, the role of VLA integrins in lymphocyte migration and recognition, and common integrin recognition mechanisms.
Synopsis: The regulation of cell adhesion is a prerequisite for establishing and maintaining a normal host defence system. One of the main classes of molecules mediating cellular adhesive interactions is the integrin, a broadly distributed family of transmembrane receptors. This book offers an overview of the structure and function of a number of integrins and also of intercellular adhesion molecule-1(ICAM-1). Topics covered include the regulation of leukocyte integrin function, the role of VLA integrins in lymphocyte migration and recognition, common and ligand-specific integrin recognition mechanisms, and the role of integrin alpha-481 in lymphocyte-endothelial cell interactions. The second part of the book highlights the importance of ICAM-1, an immunoglobulin and ligand for the leukocyte integrin LFA-1. Its role in inflammation and tumour development is discussed, as well as its relevance as a receptor for rhinovirus and plasmodium falciparum-infected erythrocytes.
Illustrations: 21, 21 fig., 11 tab.
Publication: Switzerland
Imprint: S Karger AG
Returns: Non-returnable
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