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Item Details
Title: IMMUNOPATHOGENETIC ASPECTS OF DISEASE INDUCED BY HELMINTH PARASITES
By: D. O. Freedman (Editor), H. Renz
Format: Hardback

List price: £129.10


We currently do not stock this item, please contact the publisher directly for further information.

ISBN 10: 3805564007
ISBN 13: 9783805564007
Publisher: S KARGER AG
Pub. date: 12 March, 1997
Series: Chemical Immunology & Allergy Vol 66
Pages: 236
Description: The articles in this volume present an overview of recent advances in understanding of the induction of IgE, eosinophilic, and cytokine regulatory responses to helminth infection, and reviews of immunopathogenic aspects of various infections, such as schistosomiasis, and cysticercosis.
Synopsis: Just as the magnitude of the growth and developmental problems attributable to human helminthiasis are being fully realized, we are able for the first time to describe defined immune responses giving rise to the pathological lesions seen. On the basis of the different sets of cytokines produced by CD4+ T cells, these responses can be classified according to the Th1/Th2/Th0 paradigm. Deleterious inflammatory responses to metazoan parasites appear to be consistently associated with a highly polarized Th2 cytokine profile. Thus, host-parasite models involving specific enteric and tissue helminths have provided seminal data on immunoregulatory and immunopathogenetic responses that are more broadly generalizable to the entire Th1/Th2 paradigm. The first three articles in this volume present an overview of recent advances in the understanding of the induction of IgE, eosinophilic and cytokine regulatory responses to helminthic infection.Subsequent articles comprehensively review immunopathogenetic aspects of schistosomiasis, hookworm infection, echino-coccosis, lymphatic filariasis, onchocerciasis, toxocariasis and cysticercosis, and at the same time, emphasize key directions and priorities. Conclusions from animal models of infection are set in the context of human disease wherever possible. For all immunologists with an interest in cytokine biology and for those interested in the biology of tropical infectious diseases this volume is useful reading.
Illustrations: 37, 37 fig., 5 tab.
Publication: Switzerland
Imprint: S Karger AG
Returns: Non-returnable
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