| Title:
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CHROMOSOMAL TRANSLOCATIONS AND ONCOGENIC TRANSCRIPTION FACTORS
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| By: |
Frank J. Rauscher (Editor), Peter K. Vogt (Editor) |
| Format: |
Paperback |
| List price:
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£99.99 |
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| ISBN 10: |
3642644244 |
| ISBN 13: |
9783642644245 |
| Publisher: |
SPRINGER-VERLAG BERLIN AND HEIDELBERG GMBH & CO. KG |
| Pub. date: |
2 October, 2011 |
| Edition: |
Softcover reprint of the original 1st ed. 1997 |
| Series: |
Current Topics in Microbiology and Immunology 220 |
| Pages: |
166 |
| Synopsis: |
Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets. |
| Illustrations: |
3 Tables, black and white; XI, 166 p. |
| Publication: |
Germany |
| Imprint: |
Springer-Verlag Berlin and Heidelberg GmbH & Co. K |
| Returns: |
Returnable |