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Item Details
| Title:
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PROTEIN CRYSTALLOGRAPHY IN DRUG DISCOVERY, VOLUME 20
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| By: |
Robert E. Babine (Editor), Sherin S. Abdel-Meguid (Editor), Raimund Mannhold |
| Format: |
Electronic book text |
| List price:
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£132.00 |
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We believe that this item is permanently unavailable, and so we cannot source
it.
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| ISBN 10: |
3527606351 |
| ISBN 13: |
9783527606351 |
| Publisher: |
JOHN WILEY AND SONS LTD |
| Pub. date: |
15 July, 2008 |
| Series: |
Methods and Principles in Medicinal Chemistry 20 |
| Pages: |
278 |
| Description: |
Discusses various strategies to derive high resolution structures for different target protein classes, as well as selected examples of successful protein crystallographic studies. |
| Synopsis: |
The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work. |
| Publication: |
UK |
| Imprint: |
Wiley-VCH Verlag GmbH |
| Returns: |
Non-returnable |
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A celebratory, inclusive and educational exploration of Ramadan and Eid al-Fitr for both children that celebrate and children who want to understand and appreciate their peers who do.
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