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Item Details
Title: MEDICINAL CHEMISTRY APPROACHES TO PERSONALIZED MEDICINE, VOLUME 59
By: Karen Lackey (Editor), Bruce Roth (Editor), Raimund Mannhold
Format: Electronic book text

List price: £126.00


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ISBN 10: 3527677275
ISBN 13: 9783527677276
Publisher: JOHN WILEY AND SONS LTD
Pub. date: 22 November, 2013
Series: Methods and Principles in Medicinal Chemistry 59
Pages: 408
Synopsis: Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more
Publication: UK
Imprint: Wiley-VCH Verlag GmbH
Returns: Non-returnable
Some other items by this author:
ADVANCED COMPUTER-ASSISTED TECHNIQUES IN DRUG DISCOVERY, VOLUME 3
AMERICAN PSYCHOLOGICAL ASSOCIATION MEMBERSHIP DIRECTORY ON CD-ROM (CD)
ANIMAL MODELS FOR HUMAN CANCER
ANIMAL MODELS FOR HUMAN CANCER
ANIMAL MODELS FOR HUMAN CANCER
ANIMAL MODELS FOR HUMAN CANCER (HB)
ANTITARGETS
ANTITARGETS (HB)
ANTIVIRAL DRUG STRATEGIES (HB)
ANTIVIRAL DRUG STRATEGIES, VOLUME 50
ANTIVIRAL DRUG STRATEGIES, VOLUME 50
ANTIVIRAL DRUG STRATEGIES, VOLUME 50
ASPARTIC ACID PROTEASES AS THERAPEUTIC TARGETS (HB)
ASPARTIC ACID PROTEASES AS THERAPEUTIC TARGETS, VOLUME 45
ASPARTIC ACID PROTEASES AS THERAPEUTIC TARGETS, VOLUME 45
ASPARTIC ACID PROTEASES AS THERAPEUTIC TARGETS, VOLUME 45
BIO-NMR IN DRUG RESEARCH (HB)
BIOISOSTERES IN MEDICINAL CHEMISTRY, VOLUME 54
BIOISOSTERES IN MEDICINAL CHEMISTRY, VOLUME 54
BIOISOSTERES IN MEDICINAL CHEMISTRY, VOLUME 54
BIOISOSTERES IN MEDICINAL CHEMISTRY, VOLUME 54 (HB)
BIONMR IN DRUG RESEARCH, VOLUME 16
CHEMOGENOMICS IN DRUG DISCOVERY
CHEMOINFORMATICS IN DRUG DISCOVERY (HB)
CHEMOINFORMATICS IN DRUG DISCOVERY, VOLUME 23
CHEMOKINE RECEPTORS AS DRUG TARGETS (HB)
CHEMOMETRIC METHODS IN MOLECULAR DESIGN, VOLUME 2
CHIRALITY IN DRUG RESEARCH, VOLUME 33
CHIRALITY IN DRUG RESEARCH, VOLUME 33 (HB)
COMBINATORIAL CHEMISTRY
COMBINATORIAL CHEMISTRY
COMBINATORIAL CHEMISTRY (HB)
DRUG BIOAVAILABILITY
DRUG BIOAVAILABILITY (HB)
DRUG METABOLISM PREDICTION, VOLUME 63
DRUG METABOLISM PREDICTION, VOLUME 63
DRUG METABOLISM PREDICTION, VOLUME 63
DRUG METABOLISM PREDICTION, VOLUME 63 (HB)
DRUG SELECTIVITY
DRUG-MEMBRANE INTERACTIONS
EPIGENETIC TARGETS IN DRUG DISCOVERY
EPIGENETIC TARGETS IN DRUG DISCOVERY (HB)
EPIGENETIC TARGETS IN DRUG DISCOVERY, VOLUME 42 (HB)
EVOLUTIONARY ALGORITHMS IN MOLECULAR DESIGN, VOLUME 8
FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY
FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY, VOLUME 34
FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY, VOLUME 34 (HB)
FRAGMENT-BASED DRUG DISCOVERY
FRAGMENT-BASED DRUG DISCOVERY
FRAGMENT-BASED DRUG DISCOVERY
FRAGMENT-BASED DRUG DISCOVERY (HB)
G PROTEIN-COUPLED RECEPTORS AS DRUG TARGETS
G PROTEIN-COUPLED RECEPTORS AS DRUG TARGETS (HB)
GENE FAMILY TARGETED MOLECULAR DESIGN
GENE FAMILY TARGETED MOLECULAR DESIGN (HB)
HANDBOOK OF MOLECULAR DESCRIPTORS, VOLUME 11
HIGH-THROUGHPUT SCREENING IN DRUG DISCOVERY
HIGH-THROUGHPUT SCREENING IN DRUG DISCOVERY (HB)
HIGH-THROUGHPUT SCREENING IN DRUG DISCOVERY, VOLUME 35
HIT AND LEAD PROFILING (HB)
IN VIVO MODELS FOR DRUG DISCOVERY (HB)
LEAD GENERATION
LEAD GENERATION
LEAD GENERATION
LEAD GENERATION (HB)
LIGAND DESIGN FOR G PROTEIN-COUPLED RECEPTORS
LIGAND DESIGN FOR G PROTEIN-COUPLED RECEPTORS (HB)
LIGAND DESIGN FOR G PROTEIN-COUPLED RECEPTORS, VOLUME 30
MASS SPECTROMETRY IN MEDICINAL CHEMISTRY
MASS SPECTROMETRY IN MEDICINAL CHEMISTRY
MASS SPECTROMETRY IN MEDICINAL CHEMISTRY (HB)
MEDICINAL CHEMISTRY APPROACHES TO PERSONALIZED MEDICINE (HB)
MEDICINAL CHEMISTRY APPROACHES TO PERSONALIZED MEDICINE, VOLUME 59
MEDICINAL CHEMISTRY APPROACHES TO PERSONALIZED MEDICINE, VOLUME 59
MICROWAVES IN ORGANIC AND MEDICINAL CHEMISTRY
MICROWAVES IN ORGANIC AND MEDICINAL CHEMISTRY, VOLUME 25
MOLECULAR DESCRIPTORS FOR CHEMOINFORMATICS (HB)
MOLECULAR DESCRIPTORS FOR CHEMOINFORMATICS, VOLUME 41 (2 VOLUME SET)
MOLECULAR DRUG PROPERTIES
MOLECULAR DRUG PROPERTIES (HB)
MOLECULAR INTERACTION FIELDS
MOLECULAR INTERACTION FIELDS (HB)
MOLECULAR MODELING
MOLECULAR MODELING
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY (HB)
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY, VOLUME 60
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY, VOLUME 60
NATURAL PRODUCTS IN MEDICINAL CHEMISTRY, VOLUME 60
NEW TRENDS IN SYNTHETIC MEDICINAL CHEMISTRY, VOLUME 7
NUCLEAR RECEPTORS AS DRUG TARGETS, VOLUME 39
NUCLEAR RECEPTORS AS DRUG TARGETS, VOLUME 39 (HB)
PHARMACOPHORES AND PHARMACOPHORE SEARCHES, VOLUME 32
PHOSPHODIESTERASES AND THEIR INHIBITORS (HB)
PHOSPHODIESTERASES AND THEIR INHIBITORS, VOLUME 61
PHOSPHODIESTERASES AND THEIR INHIBITORS, VOLUME 61
PHOSPHODIESTERASES AND THEIR INHIBITORS, VOLUME 61
PREDICTIVE TOXICOLOGY
PREDICTIVE TOXICOLOGY
PREDICTIVE TOXICOLOGY
PREDICTIVE TOXICOLOGY (HB)
PRODRUGS AND TARGETED DELIVERY
PRODRUGS AND TARGETED DELIVERY
PRODRUGS AND TARGETED DELIVERY
PRODRUGS AND TARGETED DELIVERY (HB)
PROTEIN CRYSTALLOGRAPHY IN DRUG DISCOVERY (HB)
PROTEIN CRYSTALLOGRAPHY IN DRUG DISCOVERY, VOLUME 20
PROTEIN KINASES AS DRUG TARGETS (HB)
PROTEIN THERAPEUTICS (HB)
PROTEIN-LIGAND INTERACTIONS
PROTEIN-LIGAND INTERACTIONS (HB)
PROTEIN-LIGAND INTERACTIONS, VOLUME 53
PROTEIN-LIGAND INTERACTIONS, VOLUME 53
PROTEIN-LIGAND INTERACTIONS, VOLUME 53
PROTEIN-PROTEIN INTERACTIONS IN DRUG DISCOVERY (HB)
PROTEIN-PROTEIN INTERACTIONS IN DRUG DISCOVERY, VOLUME 56
PROTEIN-PROTEIN INTERACTIONS IN DRUG DISCOVERY, VOLUME 56
PROTEIN-PROTEIN INTERACTIONS IN DRUG DISCOVERY, VOLUME 56
QSAR
QUANTUM MEDICINAL CHEMISTRY, VOLUME 17
SCAFFOLD HOPPING IN MEDICINAL CHEMISTRY (HB)
SCAFFOLD HOPPING IN MEDICINAL CHEMISTRY, VOLUME 58
SCAFFOLD HOPPING IN MEDICINAL CHEMISTRY, VOLUME 58
SCAFFOLD HOPPING IN MEDICINAL CHEMISTRY, VOLUME 58
STRUCTURE-BASED LIGAND DESIGN
STRUCTURE-BASED LIGAND DESIGN, VOLUME 6
TARGET DISCOVERY AND VALIDATION (HB)
THERMODYNAMICS AND KINETICS OF DRUG BINDING, VOLUME 65
THERMODYNAMICS AND KINETICS OF DRUG BINDING, VOLUME 65
THERMODYNAMICS AND KINETICS OF DRUG BINDING, VOLUME 65
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VIRTUAL SCREENING
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