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Item Details
| Title:
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BIOISOSTERES IN MEDICINAL CHEMISTRY, VOLUME 54
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| By: |
Nathan Brown (Editor), Raimund Mannhold, Hugo Kubinyi |
| Format: |
Electronic book text |
| List price:
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£126.00 |
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We believe that this item is permanently unavailable, and so we cannot source
it.
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| ISBN 10: |
3527654321 |
| ISBN 13: |
9783527654321 |
| Publisher: |
JOHN WILEY AND SONS LTD |
| Pub. date: |
18 June, 2012 |
| Series: |
Methods and Principles in Medicinal Chemistry 54 |
| Pages: |
256 |
| Description: |
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. |
| Synopsis: |
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section. |
| Publication: |
UK |
| Imprint: |
Wiley-VCH Verlag GmbH |
| Returns: |
Non-returnable |
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