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Item Details
| Title:
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FRAGMENT-BASED DRUG DISCOVERY
LESSONS AND OUTLOOK, VOLUME 67 |
| By: |
Daniel A. Erlanson (Editor), Wolfgang Jahnke (Editor), Raimund Mannhold |
| Format: |
Hardback |
| List price:
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£142.95 |
| Our price: |
£117.93 |
| Discount: |
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| You save:
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£25.02 |
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| ISBN 10: |
352733775X |
| ISBN 13: |
9783527337750 |
| Availability: |
Usually dispatched within 3-5 days.
 Delivery
rates
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| Stock: |
Currently 1item in stock |
| Publisher: |
WILEY-VCH VERLAG GMBH |
| Pub. date: |
13 January, 2016 |
| Pages: |
528 |
| Description: |
The secret of success in drug discovery written by the pioneers in the field with unrivaled experience in fragment-based methods. In this handbook, the first-hand knowledge imparted by the world's leading experts provides a comprehensive overview of current methods and applications of fragment-based discovery. |
| Synopsis: |
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets. |
| Publication: |
Germany |
| Imprint: |
Wiley-VCH Verlag GmbH |
| Returns: |
Returnable |
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